MRI Detection of Secondary Damage After Stroke

MRI detection of secondary damage after stroke: chronic iron accumulation in the thalamus of the rat brain.

BACKGROUND AND PURPOSE Iron plays a central role in many metabolic processes. Under certain pathological situations it accumulates, producing negative effects such as increasing damage by oxidative stress. The present study examined long-term iron accumulation in a stroke model with secondary degeneration, using MRI and histological techniques. METHODS Male Wistar rats (n=22) were subjected t...

Brain damage after heat stroke.

Cerebellar syndromes and radiologic cerebellar atrophy after hyperpyrexia have occasionally been reported, mostly in neuroleptic malignant syndromes, but neuropathologic studies are extremely rare. We studied 3 patients (a 74-year-old woman, a 63-year-old man, and an 80-year-old man) who had heat stroke during heat waves in France. One patient had generalized seizures and died 28 hours after ad...

Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives.

Carbamylerythropoietin (CEPO) does not bind to the classical erythropoietin (EPO) receptor. Nevertheless, similarly to EPO, CEPO promotes neuroprotection on the histologic level in short-term stroke models. In the present study, we investigated whether CEPO and other nonerythropoietic EPO analogs could enhance functional recovery and promote long-term histologic protection after experimental fo...

Use of secondary preventive drugs after stroke

i Säll är den som har till rättesnöre, att man bör tänka efter före. Persistent use of secondary preventive drugs declines rapidly during the first 2 years after stroke. Few sex differences in the use of drugs for secondary prevention after stroke: a nationwide observational study. The association between patients' beliefs about medicines and adherence to drug treatment after stroke: a cross-se...

Impact of White Matter Damage After Stroke